Hemolytic anemia and thrombocytopenia (ITP type) in chronic lymphocytic leukemia following nitrogen mustard therapy

Autoimmune hemolytic anemia is one of the differential diagnoses for anemia in patients with lymphoproliferative neoplasia, such as chronic lymphocytic leukemia, who experience sudden drop in hemoglobin. The association between autoimmune hemolytic anemia and chronic myeloid leukemia on the contrary is unusual. Here we present a patient with a background of chronic myeloid leukemia treated previously with Tyrosine Kinase Inhibitors, then developed autoimmune hemolysis simultaneously with chronic myeloid leukemia relapse. Hemolysis was treated with steroids with good response.

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Surface localization of high-mobility group nucleosome-binding protein 2 on leukemic B cells from patients with chronic lymphocytic leukemia is related to secondary autoimmune hemolytic anemia

Leukemia & Lymphoma ◽

10.3109/10428194.2014.957205 ◽

2015 ◽

Vol 56 (4) ◽

pp. 1115-1122 ◽

Cited By ~ 4

Author(s):

Pablo E. Morande ◽

Mercedes Borge ◽

Cecilia Abreu ◽

Jeremías Galletti ◽

Samanta R. Zanetti ◽

...

Keyword(s):

B Cells ◽

Chronic Lymphocytic Leukemia ◽

Hemolytic Anemia ◽

Autoimmune Hemolytic Anemia ◽

Binding Protein ◽

High Mobility ◽

Lymphocytic Leukemia ◽

High Mobility Group ◽

Surface Localization ◽

Nucleosome Binding

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Efficacy and safety of low-dose alemtuzumab as treatment of autoimmune hemolytic anemia in pretreated B-cell chronic lymphocytic leukemia

Leukemia ◽

10.1038/sj.leu.2404703 ◽

2007 ◽

Vol 21 (8) ◽

pp. 1819-1821 ◽

Cited By ~ 13

Author(s):

L Laurenti ◽

M Tarnani ◽

D G Efremov ◽

P Chiusolo ◽

L De Padua ◽

...

Keyword(s):

Chronic Lymphocytic Leukemia ◽

B Cell ◽

Hemolytic Anemia ◽

Autoimmune Hemolytic Anemia ◽

Low Dose ◽

Lymphocytic Leukemia ◽

Efficacy And Safety ◽

Cell Chronic Lymphocytic Leukemia

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Generalized subcutaneous panniculitis-like T-cell lymphoma following rituximab for hemolytic anemia in a patient with chronic lymphocytic leukemia

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2009.11.649 ◽

2010 ◽

Vol 62 (3) ◽

pp. AB96

Keyword(s):

T Cell ◽

Chronic Lymphocytic Leukemia ◽

Hemolytic Anemia ◽

Cell Lymphoma ◽

Lymphocytic Leukemia ◽

T Cell Lymphoma

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Chronic Lymphocytic Leukemia Presenting as a Subcortical Watershed Infarct

Case Reports in Hematology ◽

10.1155/2019/2089359 ◽

2019 ◽

Vol 2019 ◽

pp. 1-5

Author(s):

Mridul Gupta ◽

Divita Singh ◽

Patrick Lee ◽

Sandhya Kadiyam

Keyword(s):

Chronic Lymphocytic Leukemia ◽

Hemolytic Anemia ◽

Immune Thrombocytopenia ◽

Case Reports ◽

Pure Red Cell Aplasia ◽

Lymphocytic Leukemia ◽

Red Cell ◽

Cerebral Infarcts ◽

Autoimmune Cytopenia ◽

Watershed Infarcts

Internal watershed infarcts (WI) involve white matter between deep and superficial arterial systems of middle cerebral artery. These infarcts are considered to be either from low blood flow or microembolism. Anemia is an extremely rare cause of watershed infarcts. Very few cases of hemolytic anemia causing watershed cerebral infarcts have been reported. Chronic lymphocytic leukemia (CLL) is frequently complicated with secondary autoimmune cytopenia such as autoimmune hemolytic anemia (AIHA), immune thrombocytopenia (ITP), and pure red cell aplasia. AIHA is present in about 7–10% of patients with CLL. AIHA from CLL presenting as WI is an extremely rare phenomenon with no previously published case reports to the best of our knowledge.

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